Shrien Dewani was taken from Fromeside Hospital to Bristol Airport accompanied by officers from the Metropolitan Police Service (MPS) Extradition Unit.
Officers were met at the airport by representatives from the South African authorities who have escorted him on the flight to Cape Town.
Shrien Dewani extradited
Dewani was put on a flight from Bristol Airport bound for Cape Town
Dewani is accused of being behind a plot to kill his new bride Anni, 28, who was shot dead after being kidnapped during a taxi ride through a township on Cape Town’s outskirts.
Three men have been convicted already and are serving jail terms. Prosecutors allege Dewani ordered the killing of his wife, who was a Swedish national.
The extradition of Dewani, 34, from Bristol, brings to an end a three-year battle to bring him to court after her death in November 2010.
Dewani’s lawyers argued he should not be forced from the UK to face trial until he had recovered from mental health problems, including depression and post-traumatic stress disorder.
Mrs Dewani’s uncle Ashok Hindocha told a news conference on Monday he was relieved his family would now have an opportunity to get justice.
He said: “(I am) relieved. Hopefully this case from now onwards will be about Anni.
“Until now, it hasn’t really been about her. You cannot really blame anyone. It’s the justice system and the way it is.
“Obviously, we were extremely surprised that it took so long.”